One Life to Live premiered in 1968, centering on the lives of the citizens of the fictional town of Llanview, PA. Concentrating on the wealthy Lord family, and the middle-class Woleks and Rileys, the show was one of the first daytime dramas to depict people from all sorts of backgrounds. The show was the first to depict an interracial relationship, and among the first to explore drug addiction. It has also depicted dissociative identity disorder, cultism, out-of-body experiences, international espionage, time travel, and even underground cities!

In New York, Detective Alberto Santana comes with his partner Joseph Bruno to meet his wife Gina and his daughter Celeste to celebrate her eighteenth birthday. Out of the blue, Alberto is shot in his head on the sidewalk by a man wearing a hood that delivers a religious message from the Lord. Many years later, Celeste is a detective of the New York Police Department and partner of Joe Bruno. When the crooks Alden and Jeff Kane, who had torched their buildings to receive the insurance, are released from prison, they are executed by two criminals in the same modus operandi of detective Santana, and the police department concludes that they are the same killers. Lieutenant Diaz assigns Detective Manso and Detective Demarco from narcotics to investigate the case, for the deception of Celeste. Then the drug dealer Chino and his gang are executed in Manhattan's Lower East Side by the killers Dante and his deformed and deranged twin brother Perfecto...